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Tuesday, July 28 • 12:35 - 12:40
Analysis of genetic variants associated with infection of Mycobacterium leprae in exomes of Mexican mestizo population

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Leprosy, also known as Hansen's disease, is an infectious chorionic disease caused by the bacillus Mycobacterium leprae that mainly affects the peripheral nerves and the skin. This disease has accompanied man for at least 4,000 years and during all that time it has been one of the most dangerous diseases worldwide.

M. leprae has low virulence, to spread it is necessary the prolongated contact with the patient (close and prolonged contact) and have a genetic predisposition to acquire the disease. Mira and collaborators identified a locus within the PARK / PACRG gene that is associated with the susceptibility of the human population to develop leprosy. In mice, the NRAMP1 gene has been identified on chromosome 1, which controls both the susceptibility and resistance of intracellular pathogens.

On the other hand, several reports of single nucleotide polymorphisms (SNPs) associated with functions of resistance and susceptibility to M. leprae pathogenesis have emerged worldwide, therefore, in this project, we compile a basis of SNP data identified in all populations, associated with M. leprae pathogenesis, and compared with the SNPs identified in the "SIGMA T2D" project, a project aimed at the study of type 2 diabetes, which sequenced the exomes of around 3700 individuals of Latin American, specifically Mexican descent. This selected classification selects SNPs associated with M. leprae with greater probabilities of being present in exomes of the Mexican population for their in vitro study without the need to sequence complete exomes.

Currently, Mexico is among the 15 countries with the highest incidence of leprosy worldwide, with Sinaloa being one of the main states affected by this disease, ranking 1st in the nation in registered cases of leprosy with 150 cases registered at the end of 2019, therefore, it identifies genetic markers that help in the prevention methods of the disease is of vital importance for the development of strategies for its eradication.


Miguel Elenes

PhD Student, Universidad Autónoma de Sinaloa

Tuesday July 28, 2020 12:35 - 12:40 MSK
Zoom Conference https://zoom.us/j/94321101353?pwd=QlJBb09uM0NVVnVyK0FkbTJ3Nkcrdz09